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TIO2 stands for Titanium Dioxide. Its pigment is a fine white powder which is used ex

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

tensively in paints, plastics, papers for giving sharp whiteness to the material. It

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

ives paint high hiding power, meaning the ability to mask or hide a substrate. It doe

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

s this more effectively than any other white pigment. Today, titanium dioxide pigment

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

is by far the most important material used by the paints and plastics industry for wh

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

teness and opacity. These unique properties are derived from the refractive index of

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

titanium dioxide. The refractive index expresses the ability to bend and scatter ligh

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

. Titanium dioxide has the highest refractive index of any material known to man, gre

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ter even than diamond.

The material is used as an opacifier in glass and porcelain e

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

namels, cosmetics, sunscreens, paper, and paints. To take advantage of this property,

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

titanium dioxide must be mined, refined and ground to a fine, uniform particle size.

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ne of the major advantages of the material for exposed applications is its resistance

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

to discoloration under UV light. Titanium Dioxide is found in a form known as ilmeni

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

e which is found in the iron ore.

Main uses of TIO2:
1. Pigments – As discussed

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

earlier TIO2 used to give whiteness and opacity to products such as paints and coatin

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

gs, plastics, paper, inks, fibres and food and cosmetics.

2. Anti Microbial Coating

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

The Titania in TIO2 has photo catalytic property which make the material a candidate

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

for applications such as medical devices, food preparation surfaces, air conditioning

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

filters, and sanitary ware surfaces.

3. Oxygen Sensors – Titania can be used to sen

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

e the amount of oxygen present in an atmosphere which is used for studying atmosphere

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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