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The three most important motivators identified in the works of Maslow, McClelland and Herzberg are: basic hygiene factors (Herzberg); esteem (Maslow); and the need for achievement (McClelland).

The ba

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

sic hygiene factors form an important base to build upon. Today these basic needs are met through the package that a company offers their employees, including; the base pay, insurance, health coverage,

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

vacation days, pensions, etc… These have strong influence over employees in their decision on taking a job or leaving a company for one with a better package. This influence may be underestimated, es

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

pecially with employees who may be on the lower end of the pay scale or in entry level or hourly paid positions. Health insurance is perhaps the best example of an unfulfilled 'hygiene" need in today's

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

work place. A worker without health insurance may feel a strong motivation to search for employment that will provide health coverage in order to feel the security in knowing that they and their famil

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

ies are covered. I am an entrepreneur. I have been told by dozens of individuals that they envy me for having the motivation to start up my own company, but that they could never make the move themsel

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

ves because they fear not being able to pay for their health coverage on their own. This is an example of how these basic factors provide a foundation upon which other motivational factors are built.

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

Without these basic needs being met, workers are motivated to search for opportunities elsewhere, or when taken away, they can negatively affect motivation.

Esteem (Maslow) is the second important moti

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

vator in the workplace. I conduct leadership workshops for organizations in which I often ask the participants to list in order of importance what are the attributes of a great leader. Participants al

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ways list listening skills, allowing participation and working collaboratively on the very top of the list. As the Hawthorne experiments demonstrated, when the company listened, asked opinions and acte

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

on employee suggestions, the workers felt that it "was the best thing the company had ever done". Listening, including employees in discussions and working collaboratively helps employees feel they ar

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

e a valued part of the team. This builds their sense of self esteem and develops a healthy sense of affiliation (McClelland). I once worked with an individual who went through the motions of organizin

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

g teams, asking for input, and collaboratively working to a common solution. But when time came to make decisions he made an authoritative decision, often against the suggestions of the members of the

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

team, and took all credit for himself. The esteem of the team members dropped, they felt their opinions did not matter, they lost interest, their mood became gloomy and they either withdrew from the te

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

am or worked against the leader to sabotage the project. What had been their biggest motivator, the esteem of their group, was damaged, and the whole effectiveness of the project was damaged as a result

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

.

Closely related to esteem is the need for achievement (McClelland). Teams and individuals need to feel the sense of achievement, success, growth, challenge, etc… Most all are individuals are motiva

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

ted by achievement to some extent or another. John Kotter in his book "Leading Change" points out that great leaders "generate short-term wins". Each individual and each team needs to celebrate the in

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

cremental improvements made in individual and group performance. Without recognition of achievements, the drive for continuous growth and improvement is reduced and performance suffers.

Each of these

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

three motivators are interdependent. Without enough pay, enough benefits, etc., employees will be motivated to look for the basic needs elsewhere. Without feeling they are valued by their manager and

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

company they will not function as a high performing group. Without outward recognition, rewards, challenges, individuals and teams will not feel they have achieved anything and productivity will suffer

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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