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    An expatriate, on international business travel most of the times, arrives on the British Air Way’s flight, rents a Toyota at Hertz, drives down-town to Hilton hotels and reaches
    According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product
    the room, flips on to Sony TV and catches the glimpse of the same flashing signs of ‘Coca-Cola’ and ‘BMW’ etc. Then suddenly while watching the news on BBC a sense of disorienta
    ; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

    Examples of combination products may in
    tion sets in and they try to remember where they are Sydney, Singapore, Stockholm or Seattle? This has become a common experience, thanks to the MNC phenomenon. Multinational Cor
    lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

    porations (MNC) account for 40% of the worlds manufacturing output and almost a quarter of the world trade. About 85% of the world’s automobiles, 70% of computer, 35% of toothpas
    here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe
    te and 65% of soft drinks are produced and marketed by MNCs (Bartlett et al, 2003, p3).

    However, most of the MNCs have come up in recent times of change and globalisation. It is
    d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

    Combination pro
    evident in the changed definition of MNC i.e. till 1973 the United Nations defined MNC as an enterprise which controls assets, factories, mines, sales offices and the like in tw
    ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc
    o or more countries (Bartlett et al, 2003). However, the scope of what the term Multinational Corporation covers has changed and required two crucial qualifications vis-?-vis fir
    easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi
    st qualification requires an MNC to have substantial direct investment in foreign counties and not just an export business. While the second requisite for a true MNC would be a c
    nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically
    ompany engaged in the active management of these offshore assets rather than simply holding them in a passive financial portfolio (Bartlett et al, 2003).

    One of the most importa
    and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ
    nt motivations for companies to expand their operation internationally is the low-cost factors of production in developing countries like China and India (Papers4you.com, 2006).
    ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi
    This has had a tremendous influence on the economies of the developing countries, acting as a catalyst in their growth process. However, entering a new market in a different nati
    ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

    Following aspects would a
    on is not as easy as it sounds, with factors like local culture and local market knowledge presenting as obstacle initially. There are various ways in which a company can decide
    dd to the challenges in developing combination products:

    Which markets to tap where the combination products can do fairly well?
    Which combination prod
    to enter the market, one such model being the Uppsala model, which suggests a company should make an initial commitment of resources to the foreign market through which it gains
    cts are meaningful and rational?
    Which therapeutic categories to select?
    Which Combinations can address unmet needs of the patients?
    Do combin
    the local market know-how on the basis of which further evaluations can be made (Bartlett et al, 2003). However, there are many companies who do not follow such models and take a
    tions increase the patient compliance?
    What would be the developing cost?
    How to tackle the risks encountered during combination product developmen
    short cut to building the market knowledge by investing in or acquiring a local partner for instance Wal-Mart entered the UK by buying the supermarket chain Asda (Papers4you.com
    t?

    As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
    , 2006).

    However, in recent times most companies have recognised the need to be responsive to local markets and political needs and the management styles followed by multination
    ping new procedures for reviewing their safety, efficacy and quality.

    Professional from academic institutions, pharmaceutical industries, health care indust
    als are gradually shifting towards a trans-national strategy of ‘Think global, act local’.

    References

    Bartlett, C. et al. (2003). ‘Transnational Management’. 4th Ed. McGraw-Hil
    y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
    l, London.

    Papers For You (2006) "C/B/311. Multinational Enterprises (MNEs) in Developing Countries ", Available from http://www.coursework4you.co.uk/sprtbus35.htm [17/06/2006]
    .

    As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

    Papers For You (2004) " P/B/220. Is it true to say that many U.S. multinational enterprises (MNEs) are more economically and politically powerful than some nation states? Does t
    elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

    Companies that provide selfless information through particip
    his scenario best explain America's rise to globalism and the real power behind the White House today?", Available from http://www.coursework4you.co.uk/sprtbus35.htm [18/06/2006]


    tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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