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    Some time ago I registered at some (very popular) forum and a day after I received a letter from a forum member with a "bus
    According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product
    iness offer". I think this "offer" is a classical scam. But judge for yourself.

    In the letter it was written:

    “Good day
    ; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

    Examples of combination products may in
    ear One, Greetings and How are you today, I am Michael D* I would like you to permit me to apply through this medium for yo
    lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

    ur co-operation and to secure an opportunity to invest and do joint relationship and business with you in your country. I h
    here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe
    ve a substantial capital I honourably Inherited from my late father…”. And so on…

    In short, the Sender wrote:

    - He has m
    d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

    Combination pro
    oney.

    - The money is legitimately made.

    - There is a war in his country and he wants to escape (with the money).

    - Becau
    ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc
    e of the urgency, he is ready to generously pay for helping him.

    What he did not write was why he selected me to make “an
    easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi
    offer I could not refuse”? But I think the Sender needs not to bother himself with this question: the ego and greediness o
    nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically
    a potential victim will make him believe that he is the right person to get a lot of money for doing absolutely nothing.

    and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ
    If the victim swallows the bait, usually, he is asked to provide blank forms and invoices to the company that will transfer
    ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi
    money to him. These documents may be used by the scammers as an invitation to get a visa and also to deceive other victims.
    ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

    Following aspects would a

    After that, the victim is told that some clerk makes problems with funds transferring, and that it is necessary to bribe t
    dd to the challenges in developing combination products:

    Which markets to tap where the combination products can do fairly well?
    Which combination prod
    his clerk with a sum of money that is only a small part of the future “income”. After the victim transfers the first amount
    cts are meaningful and rational?
    Which therapeutic categories to select?
    Which Combinations can address unmet needs of the patients?
    Do combin
    of money, he will continue hearing endless stories about “unexpected” (but always the “very last”) fees, bribes and taxes.
    tions increase the patient compliance?
    What would be the developing cost?
    How to tackle the risks encountered during combination product developmen
    The victim can’t stop paying all this “fees” since he already gave an essential amount of money and hopes that this is inde
    t?

    As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
    d the “last fee” and the “treasure chest” is on the way. But at some moment, the victim refuses to pay the next fee: either
    ping new procedures for reviewing their safety, efficacy and quality.

    Professional from academic institutions, pharmaceutical industries, health care indust
    because he can not raise more money, or because he realized that he failed.

    What will happen after that?

    - First option:
    y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
    the criminals disappear in their country. I think this is the Happy Ending!

    - Second possibility: the victim is invited to
    .

    As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
    the country to see for himself that “there are almost no obstacles to money transfer”. And this is a very dangerous scenar
    elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

    Companies that provide selfless information through particip
    o: if the victim decides to accept the invitation he will surely pay a lot of money and may even be killed by the criminals


    tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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