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There is more than one printing option available for media replication. When selecting a facility to produce your project, their ability to both offset and screen print on media is important. There are situations

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

where offset or screen-printing is best, and the project requirements, rather than a replicator's abilities, should determine which method is used. No single format fits every project.

Technical Differences Betw

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

een Offset and Screen Printing

The first step in the screen printing process is burn the images from the electronic artwork on to film positives. During the process, ink is pushed via a squeegee through a f

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ne mesh screen onto the disc.

With offset printing, the image is burned directly onto printing plates. Rollers push ink onto the printing plate and then the image may be transferred to the disc's surface. This i

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

s essentially the same process as offset commercial printing on paper or board.

Offset Printing Considerations

Offset printing is more cost effective on runs in excess of 5,000 units. Set

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

up time required to offset print is greater than that for screen printing, forcing most plants to add an up-charge for runs under 5,000 units.

Offset printing provides better results for more complex artwork, su

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

ch as photographs, gradations, or images using percentages of colors.

For most projects, matching the media label printing with it's packaging is vital to the project's appearance. This is a job for printing ex

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

perts. The two biggest challenges in matching print are surfaces and printing process.

Printing on different surfaces is an unavoidable fact of media replication, and varied surfaces yield variations in p

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

int. A DVD absorbs ink differently, for example, than a cardboard package.

Most large quantity paper and paperboard packaging is printed offset. It is much easier to match an offset-printed media label to off

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

set-printed packaging. Using the same printing format for media and packaging is the best way to ensure consistency in your final product.

Offset prints 175 line screen and requires at least 300 DPI artwo

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

k. The higher line screen produces a smoother surface.

Most offset projects are printed 4-color process with a white flood coat. While the appearance of an image created under 4-color process screen printing ca

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

n be degraded by the line screen (this happens with areas of solid color, for example), this is not an issue for offset printing. Complex images as well as solid colors reproduce boldly under 4-color process offset

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

printing.

Offset tends to dull because the process inks are transparent and a higher resolution is used.

Offset printing involves additional setup steps unnecessary in screen-printing. These steps can some

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

imes impact a project's delivery date.

Screen Printing Considerations

Runs as small 1,000 can be produced without an up-charge.
It is easier to custom match a particular color with screen

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

printing. Any PMS can be printed, and it is even possible to mix PMS colors. Some PMS colors do not have representative CMYK equivalents, such as the 180-190 ranges of red or the 280-290 ranges of blue. In these

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ases, printing the specific PMS color is better for optimum results.

Metallic and fluorescent inks can be used in screen printing. Some corporations and institutions have their own proprietary colors. These co

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

lors can be purchased for screen printed projects.

Solid colors using 4-color process artwork do not print as well in screen as in offset.

The average line screen is 133. Due to the lower line screen, the

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

surface is not as smooth.

Proofing Print Media Printing Projects

Most jobs use PDF files as the project proofs. These are not fully accurate for color, but they do accurately show image placement.

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

Print check discs are another way to assure the quality of your project. This is a data-free CD or DVD that accurately reflects how the final product will look. Print check disks cost roughly $300 and will add

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

three to four days to a project time line. For this reason, they make the most sense for larger runs. In fact, printing for runs of 50,000 units or more should not start until the client approves a print check disc

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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Remember the old story of the ant and the grasshopper, and how the grasshopper assumed the weather would always be good so he didn't look to gather food for when times got tough? When it comes to gaining market share and growing their customer base, a lot of businesses are like the grasshopper - they have no plan, and they just assume and hope things will be okay. Are you run your business like an ant or grasshopper. Read this article and find out.

So what's hot when it comes to nurse's clothing? Scrubs are the hottest thing on the market, but forget white. You'll have to do some serious shopping if you want solid white. There just isn't much of a demand for it except in certain apparel and specific places.

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