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When creating a document, whether for screen or professional reproduction, adding a color can make a definite statement, catch your audiences attention and judicious use of color has been proven to i

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

ncrease sales and conversion rates considerably.

Adding color to a web page, this poses little problem. Pick your color and there it is. But if you are having your document reproduced on paper, what

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

type of color required by your design should be one of the major considerations.

Spot color

When thinking of color on a document, this is what most people think of. Spot color is

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

est suited for such things as solid borders, colored text, and colored lines.

It is defined by Pantone, an industry standard in color as: “Any color produced without screens or dots”.

“Screening”

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

in it's most simple definition, refers to lightening or making a color more transparent by reducing the overall coverage. In the offset process, this is accomplished by “blocking” a percentage of the

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

overall coverage through the use of dots. More dots result in a heavier coverage and less transparency. This should not imply a spot color cannot be screened, merely the color itself is not produced

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

through the use of a screen.

RGB

RGB stands for “Red, Green, Blue”, the three primary color components utilized in this system. You are probably already familiar with this one. M

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

any graphics software will manipulate color through the use of some variation of RGB, as do many desktop color printers, although these will also include black for obvious reasons.

When printing RGB

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

colors we get into what is known as “process color”. The most common is four color, but three color process works along the same principal, which I will cover shortly.

RGB is capable of reproducing

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

photographs and color artwork, but it is not a substitute for four-color process if a true color reproduction is required.

Very few printing companies will work in RGB, converting such work to the C

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

YK format instead. This is very important to keep in mind when outputting files for transport to a printing company. If your software allows, you should always convert your work to CMYK and verify yo

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ur colors.

CMYK

CMYK denotes “Cyan (blue), Magenta (red), Yellow, and blacK”. CMYK is the basis of four-color process and of nearly every high resolution color photo printed. You c

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

ould also have six, eight, or more colors, but we'll stick to four. Also note, the letter “K” is used to denote black, this is done so as to not become confused with blue.

Process color reproduction

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

works using series of colored dots of a specific size placed in a certain pattern. If you grab a magnifying glass and look at a color magazine cover, you will see a sample of process color. Individua

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

lly, each color is rather bland, but when looked at as a whole, the human eye is fooled into seeing the overall colors and shades. This is really the only practical method to reproduce full color pho

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ographs or artwork on a printing press.

As you can see, the methods required to output your color document can become quite complex rather quickly. You should always keep in mind the final output eq

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

uipment, the medium being used and what your color requirements actually are. People tend to take color for granted when designing on their desktops. Putting together a full color website, with load

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

s of photographs poses no problem, but if you were to try and print that fantastic home page on your desktop, you would probably be buying a lot of new cartridges.

Even though technology has advance

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

to the point of bringing photographic printers into the home, designing a document to take to your local printer should be given serious consideration as to the amount of color used. This single fac

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

tor alone could add a significant increase in the overall cost and labor involved.

So keep these fact in mind when designing your documents and you'll be on your way to better images and lower costs

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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