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Several pieces of equipment are used for die cutting. There are three basic types of c

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

utting equipment. The first is a small swing arm ‘clicker’ press that is ideal for emb

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

oidery shops. The second is a large ‘traveling head’ press, which is used for multiple

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

cutting and roll cutting. ‘Full head’ press is the third type, and it is used for heav

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

y-duty jobs. Additionally, ‘up-acting’ hydraulic platen presses are available for spec

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

al applications such as cutting jigsaw puzzles, circuit boards and screen-printed mate

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

ial. Automatic die cutting equipment is excellent for cutting large-formats such as pa

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

per, labels, coupon books and plastic membership cards.

Other types of die cutting eq

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ipment includes clicker punch presses, both automatic and manual roll feed and beam pr

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

sses. A trained professional is required to select the right die cutting equipment for

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

the right job. For simultaneous scoring and die cutting, low-cost steel-rule dies are

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

used. Hollow die cutting equipment is perfect to create small-format items such as lab

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

ls that do not require scoring and embossing. For efficient running, this equipment ne

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ds expensive solid-metal dies made of high-quality steel. Modular designed die cutting

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

equipment is the most flexible.

The main features of good die cutting equipment are

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

igh speed, ease to set up and user friendliness. ATOM S530BP CNC die cutting equipment

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

is one of the most modern and versatile instruments for the cutting of both sheets and

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

rolls. Its maximum speed is 90 strokes per minute and can save material from 15 to 35

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

. This special die cutting system is planned to replace three to seven existing travel

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ng head die cutting presses. It is an ideal solution for saving both material and time

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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