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Packaging is very important for the sale, storage and shipping of supplies. The i

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

mportance of packaging increased significantly after the Industrial Revolution bu

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

its usefulness is not new. Even in the times of yore, clay, glass and leather co

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

tainers were used for these purposes. In modern times packaging has become a com

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

lete science which studies all aspects of the product to be packaged; for example

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

its sensitivity to light, air, moisture, chemical reaction, degree of fragility

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

nd more. It also tries to find a solution to increase protection and decrease cos

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

t. Apart from the science and economics of packaging, its aesthetic sense and cre

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

tivity is equally important.

A major portion of packaging is used for food. Pack

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ging for food is mostly cheap as well as light, and can fit any preferred size. A

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

art from these, packaging elongates the storage period of the products. To store

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

olid and liquid food, glass containers are preferred due to their chemical resist

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

nce, clarity and durability, whereas for boiled or frozen food, cosmetics, pharma

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

eutical substances and toiletries plastic is used. For packaging of liquid, metal

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

or plastic containers are used.

Customized packaging, however, meets the specia

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

needs of the product. Different materials are used for packaging different goods

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

For lighter goods, corrugated or solid cardboard is used. Cardboard cartons are

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ight, economical and easy to manufacture, print and store. For heavy loads, wood

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

s required. Products weighing more than a hundred kilograms come in timber cases,

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

and for the merchandise weighing less than a hundred kilograms fiberboard is used

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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