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Christmas Decorating began in the 1500's. Christmas Ornaments on trees first began in Germany. In Latvia around 1510 a fir tree (which is a traditional Christmas Tree still t

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

oday) was decorated with ornaments of roses. Then they began to use wafers, nuts, and candles. Also Christmas ornaments of cookies and candy were being used and they are still

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

used today. Mothers and children get together and bake the cookies and candy and decorate them to hang on the Christmas Tree. Some families make this a tradition every Christ

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

mas. In earlier years there were also painted ornaments made of wood and late with blown glass.

To this day the most beautiful Christmas ornaments come from Germany. Many orn

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ments have a story behind them and are passed down from generation to generation. Christmas ornaments hold many beautiful memories for families. The ornaments hold a roadmap o

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

f memories for all families. The Christmas holiday is celebrated all over the world. It is the birth of Jesus Christ. The stories come from the Gospels of Matthew and Luke.

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

The nativity sets, which almost every home has and displays, is a replica of at the place where Jesus was born. Again the most beautiful nativity sets are made in Germany.

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

They are called nativity creches. Finland has Santa Claus. Russia has traditional handmade Christmas ornaments whereas Germany has Christmas markets. Christmas is the time of t

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

e year when families get together and exchange gifts, cards and celebrate the birth of Jesus Christ and families pray together and share memories of the past. There is also ar

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

rival of Father Christmas (Santa Claus) on Christmas Eve

Christmas Day is on December 25. It is preceded by Christmas Eve on December 24, and in is followed by Boxing Day on D

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ecember 26.

It is also a tradition to decorate outside of the houses, hang banner on street lights and some houses display Christmas villages also. When one thinks of the Ch

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ristmas holidays our thoughts turn to the birth of Jesus. also we think of mistletoe, ivy. holly, snow covered hills, carolers, ringing bells and beautiful decorated homes. Iv

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

, mistletoe and holly and ivy are winters magic to admire. Christmas time with all the decorations and happy memories help to brighten up the cold days of winter and bring a f

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

eeling of warmth to everyone.

Mistletoe is always very popular at Christmas time. It is called the kissing plant. It is hung in doorways and anyone standing under it will be

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

kissed. This tradition comes from the Norse Myths. Also in some European countries it is believed to have healing powers and is used year around for this purpose.

Holly an

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

other popular green at Christmas is believed to have magical powers. Germans consider holly to be a good luck charm against hostels enemies. As the Christmas season has grown

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

over the centuries, food has become important. Batches of cookies, candies and sugared fruit are prepared several weeks in advance being brought out on Christmas Day.

Today a

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

s centuries ago people still decorate with holly, mistletoe, ivy, and namy lights. Children enjoy stringing popcorn and cranberries, baking cookies, using colored ribbons, pap

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

er stars and any colorful materials for decorating the tree on Christmas. But one never forgets the beautiful ornaments that come from all over the world. Many families buy

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

one new ornaments each year and these are passed on from generation to generation. Holiday decorating is still popular today as it was hundreds of years ago and always will be

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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The title of this article sounds like simple advice, but so often we undertake activities and projects without really understanding how they are going to help us to achieve our aims. I have outlined below some of the causes of this cavalier (and costly) approach to business improvement along with how we might approach things differently.

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