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The function of a Conveyor Chain is to drive the system by transmission of power. It is mainly used when co

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

ntinuous transport of materials for some distance is undertaken. To suit the handling requirement for each

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

aterial, case specific attachments from the large variety that is available are chosen and added on.

Usual

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

y the chains are made from blocks, either solid or laminated. They are connected together by pins and side

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

lates. Deep-plates provide more carrying capacity. The chains may be welded or non-welded. Sprockets, which

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

have a number of teeth, synchronize with the slots in the chain and move it. In some patterns, the sprocket

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

are driven from one side only. But for circuitous lines they are driven from both sides.

A chain system,

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ncluding its parts like sprockets, pins, rollers and, sleeves or plates, can be made from carbon steel, sta

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

nless steel and plastic. Steel parts are normally heat treated for greater toughness. The choice of the mat

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

rial used in manufacture depends on the type of application. A system meant for the mining industry, for in

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

tance, would be different from the one that is installed for a tire factory. For bakery or vulcanizing oper

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ations the chain has to withstand high levels of heat. In a freezing plant the conditions are just the oppo

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

ite.

To make the chain corrosion resistant, nickel coating is applied. The product is usually supplied wit

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

or without lubricants. Maintenance-free pre-lubricated chains are also available. These not only reduce op

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

rating costs, but also prevent contamination by oil dripping on the materials carried.

The factors to be c

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

nsidered while selecting the chains and attachments include the type of material transported, size and weig

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

t, distance involved, speed at which the system operates, temperature, contact with corrosive materials and

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

noise level. Plastic parts normally generate less noise than metal ones.

Check with the manufacturers and

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

our consultant before making the investment decision. And remember that all chains and related products hav

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

to conform to the standards set by the U.S. Government and the National Association of Chain Manufacturers

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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