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Pallets are platforms or stands that are used for transportation and storage of goods. They are used particularly in industrial

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

applications like export of chemicals, grains, pharmaceuticals, perishables, and others. There are different kinds of pallets

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

used for different applications: rackable pallets that are suitable for multi-rack storage systems and non-rackable pallets tha

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

are suitable for heavy weight storage applications at floor level. Pallets are also categorized as static/ dynamic and light /

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

medium /heavy /extra-heavy. Printers pallets, double-sided pallets, four-sided pallets, shuttle pallets, newspaper pallets, rol

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

cradle pallets and reinforced pallets are the other kinds of pallets available.

Pallets can be made of either plastic, cardbo

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

ard, or wood. Wood pallets are very cost- effective but have problems like fungus, nails and splinters, pests and insects. They

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

are also difficult to dispose of, and hence, they are being increasingly replaced with plastic pallets. Light-weight thermoplas

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

tic pallets are gaining popularity because they are recyclable, insulating, light weight and environment friendly. Besides, the

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

do not have the problem of being infested with insects. Cardboard pallets, on the other hand, are fragile and are thus not sui

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

table for all kinds of applications.

Pallets are used for storing goods at one place and also for taking goods from one place

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

to another, like factory to warehouse or warehouse to stores. These days, pallets are being manufactured using very advanced te

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

hnologies to make them stronger and more durable. Some pallets are also insulated, which makes them ideal for storing perishabl

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

es. Pallets should be ideally FDA/UDSA compliant, UL fire rated, hygienic, and easy to clean.

Pallets come in different sizes,

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

most commonly 800mm x 1200mm and 1000mm x 1200mm. There are also many different designs that can be customized as per user requ

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

irements. Wooden pallets are priced at $8 to $10 if new and around $4-$6 if used. Old wooden pallets are either refurbished or

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

ade into wooden chips, compost, animal bedding, or landscape mulch. There are many companies that sell refurbished pallets. The

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

y also undertake repair and maintenance of the pallets. These days, pallets are also being attached with radio frequency identi

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

ication technology to make tracking easier.

Pallets can be ordered online at exclusive manufacturer websites. The internet is

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

a good source for comparing prices and options of various products. There are many sites that provide information about pallets

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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