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How much does it cost you to ship the empty space in your boxes? Do you know the difference between dimensional weight and oversize fees that FedEx, UPS and DHL

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

charge their customers? At what point is it less expensive to use a freight carrier instead of FedEx, UPS or DHL? Most importantly, do you know how to save mone

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

y on your shipping expense by making good packaging decisions? The answers to these questions and more make up the body of this article.

Oversize charges only a

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

pply to ground shipments and dimensional weight adjustments only apply to air shipments. Let’s say you are shipping a 20 pound, 30 x 30 x 30 inch box from New Or

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

leans to Los Angeles via UPS ground. Your cost would be $114.75. If the same box weighed 90 pounds your cost would still be $114.75. If you shipped two 10 poun

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

d boxes each 15 x 15 x 15 inches via UPS ground your cost would be $46.34. Shipping the two smaller boxes instead of one large box would save you $68.41.

Use th

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

is formula to calculate ground oversize charges:

Length + 2 x Width + 2 x Height = Oversize Charge

83 inches or less = no oversize charge
84 – 107 inches

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

Oversize 1, a minimum charge of 30 pounds
108 – 129 inches = Oversize 2, a minimum charge of 70 pounds
130 – 165 inches = Oversize 3. a minimum charg

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

e of 90 pounds plus a penalty
166 or more inches can not be shipped via ground service.

Let’s look at a 30 x 30 x 30 inch box, 20 pounds being shipped via F

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

edEx, 10:30 AM next day delivery from New Orleans to Los Angeles. Your cost would be $516.35. Shipping two 10 pounds boxes of 15 x 15 x 15 inches via FedEx next

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

day 10:30 AM would cost you $81.84. Your savings for using the two smaller boxes would be $434.51.

The formula for calculating dimensional weight or domestic

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

air shipments is:
Length x Width x Height divided by 194 = DIM weight

The formula for calculating dimensional weight for international air shipments is:

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

Length x Width x Height divided by 166 = DIM weight

Lots of money can be saved by using smaller boxes instead of larger boxes for lighter weight shipments. An

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

other way to save on air shipments that weigh over fifty pounds is to use air cargo service. For domestic air cargo shipments of 50 – 1000 pounds per pallet/box

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

with low dimensional weight, can be up to 60% less than a trucking quote. Transit time is usually three days. Savings can be greater if the freight is picked-up

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

on a Friday. If the class is over 250 the savings are better still. For international shipments air cargo can be less than FedEx, UPS and DHL if the weight is

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

over 40 pounds. The destination country will determine at what weight/dimensions there is a cost savings. Verify that all customs fees, fuel and documentation c

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ost are included in the quote. Compare your freight quotes against FedEx, UPS and DHL. If you are willing to have a pick-up on a Friday then put that informatio

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

n on your quote request. Indicate that you want an LTL and a deferred air quote.

There are ways to cut the cost of oversize three ground shipments almost in hal

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

f while saving 20% - 45% on air charges. Other fees like the $7.00 - $16.00 weekly pick-up can also be eliminated if you know where to get your shipping services

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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