Just Other Articles - Internet and Businesses Online

I know the header to this article sounds stupid and confusing, but it certainly describes where I am at the moment.

Sometimes I think I understand a concept, recognize it and accept it a

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

s a fact. Then something happens and I realize I really did not understand it at all, and still do not.

Because I have been working at developing readership on my site, I have been able

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

to lower my Alexa rating from a 3-month average of 4,313,696 the day I started my Blog to its current 3-month average of 118,981.

Alexa ranks all web sites around the world in order of t

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

eir traffic rank, the lower the rank the greater the traffic to the site. Pundits tell me that if your traffic rank is lower than 100,000 it is a big deal.

The 3-month average always lag

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

s behind my 1-week average and my yesterday average.

Currently my 1-week average is 102, 276 and has been as low as 82,711. The yesterday average does not always show up in my Alexa rank

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

ng but it has been as low as 49,279.

I recently celebrated the 5-month anniversary of Ed Bagley's Blog and feel pretty good about what I have been able to accomplish given my knowledge l

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

evel and nontechnical nature. I am a writer and not a tech head.

Included in the Alexa report is also some mind-boggling statistics about the makeup of my Blog readership.

My Blog origi

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ates in Lacey, Washington in the United States of America. I would figure that the majority of my readership would be from the USA, and I would be dead wrong.

Would you believe that only

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

25% of my current readership is from my own country? This fact just blows me away. You could knock me over with a feather.

I find it incredible that 19% of my readership comes from Chin

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

, 14% from Indonesia, 12% from the Palestinian Territory and 9% from Iran.

My Blog is in English and I have to believe that the 54% of readers in China, Indonesia, the Palestinian Territ

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ory and Iran—these four countries or territories alone—must have English as their second, third or even fourth language.

What is it about the writing of my Blog that attracts these reade

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

rs from these far away places?

I have not a clue.

I surmise that these readers must be among the educated, literate and affluent in their culture.

Considering that best estimates put t

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

e current number of web sites worldwide at 700 million, one can only imagine how many people have email addresses and do not yet have a web site, but it has to be even a far greater numbe

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

r.

Truly the Internet is bringing everyone in the world closer. Readers in China may as well be in the rec room at my home; they certainly are tuned into what my mind is putting on the I

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ternet.

I do not consider my writing to be controversial, at least not in the sense of hundreds of other bloggers on the Internet who spew out lighting rod material constantly.

I also f

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ind it incredible that I am currently the 5,509th most popular site in Indonesia, or the 64,201st most popular site in China, a nation of 1-billion-plus people.

How could I be the 9,823r

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

most popular site in Iran when I do not even write about Iran, or the Middle East? I do virtually no commentary on the Iraqi War, and talk very little about politics. Of the more than 21

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

4 articles I have written and published in 4 months, only 2 are about politics.

My current Alexa ranking in the United States is 39,953 but comes up as 118,981 because the latter is a wo

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

ldwide ranking.

The world is truly getting smaller, and my mind is getting larger every day.

I do not have any adequate words to describe the impact of the Internet on my life. Perhaps

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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