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So I'm sure many of you read the title and thought, "Where is he going to go with this one?"

Okay, I agree it sounds corny, but it is amazing how y

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

our mind frames things early on a cold, wet Midwest winter morning walking to the train station (remember, a perfect morning involves staying in my

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

sweats, not leaving the house, working on the computer). Now granted, I do hope most of us are potty trained better, have a more permanent residenc

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

and a sharper mind when it comes to avoiding traffic, but stay with me and read on.

Both bloggers and pigeons are:

1. Vastly colorful and indivi

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

dual. The flock of pigeons that served as my inspiration reminded me of how unique each one was physically. At a glance they may appear similar wh

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

en you see a flock together as a tapestry, yet, it is remarkable how distinct the markings are to each bird. Just like our blogs; each possesses pe

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

sonal font-image-layout-color preferences, variances and nuances specific to distinguish us.

2. Tend to bobble, hunt and peck. I don't know about

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

you, but I feel I resemble a pigeon as I hunt and peck across the keyboard with my head bobbling most the day! It's crazy too how their always pec

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

king at something they can see on the ground, or think they can see, and I can't see it! Do we do that?

3. Friendly and respectful. Pigeons and

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

loggers are a genuinely friendly, communal group. Even when pigeons are being fed they are respectful to one another as they go in for their share-

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

-unlike seagulls. Granted, every now and then, one in the group gets a little "randy" and starts climbing on the other, but we know the motivation

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

behind that behavior. Overall, they get along tremendously.

4. Pigeons have much to say. Ever notice how much cooing goes on-especially when the

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

congregate? I am amazed everyday as I sit with my feed reader at the wealth of intellect and insight shared daily amongst us all! Maybe that's wh

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

y pigeons huddle too, because they have so much to share with one another!

5. Are free to travel. Well, bloggers can travel anywhere Wi-Fi to blo

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

g, but isn't that almost the same today as having wings? What a beautiful thing to no longer be bound to a brick and mortar model and be able to bl

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

g from the beach (its really funny here in Chicago along lakeshore beaches we have both pigeons and gulls out in the sand!).

6. Helpful. Fellow w

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

orldwide bloggers I have been privileged to "meet" are some of the most amazing people I have ever had any fellowship with. Although most bloggers

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

are willing to lend a hand with information or a project, if they have the time, don’t forget that they might have to refuse or even not reply becau

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

e of time constraints, heavy workloads, set principles, or a simple distaste with your lack of proper etiquette. You know what I am saying, don't g

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

et so consumed with your own needs that you behave or come across disrespectfully to your fellow bloggers. Even pigeons do get ruffled and fly away

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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