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A few years ago it did not matter whether you had a .com type domain or an extension specific to your own country.

In fact, I would go so far as to say that it was probably con

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

sidered quite 'cool' to have a .com domain. It gave the impression that you were serious about your business.

Then Google decided to go local and now most local country searche

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

would probably go through the version of Google specific to your own country.

When Google launched my country's local version of Google (www.google.co.za) I investigated the m

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

tter of having a .com domain versus having .co.za domain and how that would affect where you would show up in the SERPS (search engine result pages).

I searched through various

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

forums (on Google itself) as well as other big forums like WebHostingTalk. I also did my own tests. The consensus seems to be that you will only show up in the regional search e

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

gine of Google (and I specifically refer here to using your country's local Google to LIMIT results to your country's results) if 1) your domain extension (e.g. .co.za or .co.

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

uk etc.) corresponds with the region, or 2) your IP of the hosting server falls in the corresponding geographic region or

The implication of this is that if your domain ends i

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

a .com AND you happen to be hosted physically on an internationally located server, your .com domain will NOT show up in www.google.co.za when the search is limited to South Af

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ican results. (How do you know whether your domain is hosted locally or off-shore? There are technical ways to find out but the easiest would be to ask your hosting service pro

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ider!)

Now you might argue that people might not use the 'Limit to results' option - that they might search world wide. That might be so, but here is another c

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

rveball: Even when presenting world wide results, the regional Google search engine gives a preference to local domains.

So here is the bottom line: - When you have a .com web

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

site, make sure that the physical servers that they are hosted on are located locally in your own country - If you have the option (and your business is aimed at your local mar

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

et), always register a local domain for your business website.

If you currently have a .com domain that is located off-shore, you will NEVER show up in the local results of Goo

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

le (if you specifically limit the searches to your own country's results only), and even when people do not limit the results to your country only, you will compete against mill

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ons of other .com domains, while your local competitor with a local domain extension will sneak right up to the top results in Google because Google gives more preference to tho

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

e domains when using its local version of the search engine.

What can you do about this? I would suggest that you register a local domain and start migrating your webiste over

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

to the new domain. You can leave your business cards and company brochures with your .com extension until you run out and have to print new ones in any case - all you need to do

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

is ask your webhosting provider to put a forward on your .com domain to your local domain name.

It will take a while for the transition to show up in all relevant search engine

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

and to be frank, this might not be a painless process! But you need to decide how important it is to you to show up on the first pages of the local search engines - there are o

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

her ways of marketing your website too. But if you think that you might be losing out on targeted traffic, I suggest you bite the bullet and go for it - rather sooner than later

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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