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The registry of ru-domains reports, that the

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

number of domain names registered in Russia's

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

national domain, the ru-domains, has increase

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

19.82% in the first half of 2004 to 256.356

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ru-domains.

Ru-Center compares this to the gr

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

wth of 2003, which was 16.02% for the first h

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

alf of 2003.

The increase among ru-domains i

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

Russia is coincident with the rising numbers

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

of Russian Internet users. Ru-Center explains,

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

that the weekly users numbered 5.9 million Ju

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ne 2004 , 1.4 million more than one year earli

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

er. The number of Russian Internet users is ex

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

anding 30% a year.

ICANN accredited registrar

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

Secura is accepting registrations of ru-domai

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

s by non-russian enterprises and private peopl

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

e. According to the experience of this registr

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

r, the ru-domains owned by foreign registrants

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

is growing rapidly (.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

nregistry.de/ru-domain.html" target="_new">htt

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ps://www.domainregistry.de/ru-domain.html)

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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