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There are a lot of real time backlists available for mail administrators and ISPs to use. These blacklists may

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

vary in their criteria of blacklisting an IP or a domain, or in their whitelisting process but all exist to f

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

ight spammers and stop spam.

An Open Relay Blacklists prevent messages from servers who have been identified

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

as open relay. Messages from open relay sever are likely to be spam since this type of server allows non authe

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

nticated source to relay emails to any address in the internet.

Whenever you got caught in this type of black

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

list, you have to resubmit your IP to their checking queue. http://ordb.org/submit/. Usually it takes 72 hour

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

s before your request is processed.

Another real time blacklist is the SpamCop Blacklist (SCBL); SpamCop allo

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ws recipients of unsolicited commercial email (commonly known as spam) to report the offense to the ISP or web

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

host of the spam-sending address. These reports are then compiled by the SpamCop generating the SCBL. Other l

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

egitimate senders land in the SCBL for several reasons. First and foremost is the fact that their IP is shared

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

by other users of their ISP. Furthermore, these legitimate senders can also be included in the SCBL as a resul

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

t of careless or over zealous reporting of spam.

If you are included in the SCBL accidentally, you can report

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

your complain to mailto:blproblem@admin.spamcop.net. But if you have sent a spam in the past, you will get de

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

listed automatically within 48 hours from the last spam report.

Spam Prevention Early Warning System (SPEWS)

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

is another type of public blacklist. SPEWS doesn’t rely on reports unlike SCBL, once you landed on the SPEWS l

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ist, there is little an end user can do. SPEWS doesn’t rely on requests for delisting either. You have to stop

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

sending spam, or stop your involvement on spammers (hosting spammers or selling spamware) for SPEWS to remove

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

you from their list. In addition SPEWS makes use of honeypots. These honeypots are servers/addresses that ha

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

ve not received any legitimate emails since they are dummy addresses – addresses that have not sent an email.

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

Other blacklists are Spam and Open Relay Blocking System, Vipul’s Razor, Pyzor, Spamhaus, MAPS, SpamFire, etc

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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