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If you have just started your own opt in list or are thinking of starting one you need to decide whether you want to use single opt in to collect subscribers instantly or use

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

double opt in to collect subscribers after they have confirmed.

This debate has been continuing for years now and each side has legitimate reasons for using their preferred c

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

oice but if you are unfamiliar with the situation you need to know what the facts are before you decide which to use for your opt in list.

Single Opt In

The main benefit of

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

sing single opt in is that everyone who subscribes to your newsletter or ezine via the subscription form on your website will start receiving your messages instantly without a

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

y additional requirements. Once they fill in their name and email address and hit the subscribe button your auto responder messages will start being sent.

Using single opt in

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

will mean that you collect far more subscribers for your opt in list and some list owners have reported collecting five times as many leads than using double opt in because th

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

vast majority of people simply forget to confirm their subscription.

The argument against single opt in is that its more risky because subscribers don't have to confirm thei

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

r subscription which could result in more spam complaints. But people who forgot they subscribed and marked you messages as spam would do that whether you are using single opt

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

in or double opt in because they didn't remember joining your list.

If you are worried about people maliciously entering leads into your subscription form it won't be a probl

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

m if you are using a service such as Aweber because they have advanced software that will detect suspicious subscriptions and these leads will receive a confirmation message t

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

make sure they really did subscribe.

Double Opt In

The main benefit of using double opt in is that everyone who subscribes to your newsletter or ezine via the subscription

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

orm on your website will be more likely to remember you because they actually had to confirm their subscription by clicking a link in a confirmation email that was sent to the

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

and it also means that these subscribers will be more active.

Using double opt in will mean that your subscribers are far more responsive because you will know that they act

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ally check their email and they are not just using a junk email account which they rarely check and use to subscribe to many different lists.

The argument against double opt

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

in is that it reduces the amount of subscribers you collect by a huge amount and therefore increases the time and effort it takes to build a large opt in list. If you are usin

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

a backend offer on your thank you page your subscribers will only see it after they confirm which results in fewer sales and profits.

Its important to note that if you are b

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

ying leads you should always use double opt in because these subscribers will not have seen your website and will not know who you are so the chances of getting spam complaint

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

are very high. Auto responder services such as Aweber and Get Response always use double opt in for leads that subscribe using your auto responder email address (single opt i

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

is only available for subscription forms).

Which option you choose is completely up to you. If you want to build your list as fast as possible and get the maximum amount of

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ubscribers you should use single opt in but if you are happy to reduce the amount of subscribers you get and have a safer and more responsive list you should use double opt in

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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