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    For the sake of this article, let us just assume that you already have a subscribe
    According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product
    r list of several thousand, and have been mailing them regularly.

    Initially, your
    ; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

    Examples of combination products may in
    list was relatively responsive, and you were making a nice sum from your list eac
    lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

    week. Unfortunately, though, as your list has grown, your list has become less r
    here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe
    esponsive.

    First off the bat here, let me tell you this – the responsiveness of y
    d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

    Combination pro
    our list will go down as it ages. So there is no cure-all. What we can do, howev
    ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc
    r, is try to rejuvenate the list, by getting the people on it excited about the su
    easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi
    bject matter of your list again. But you still must recognize that some people we
    nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically
    re looking to buy something specific when they joined your list, and at this time
    and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ
    hey are no longer interested. You cannot fix that.

    What you can do is improve th
    ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi
    e responsiveness of the people on your list who are no longer opening your emails.
    ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

    Following aspects would a
    One of the things that I have found to be very productive to increasing the resp
    dd to the challenges in developing combination products:

    Which markets to tap where the combination products can do fairly well?
    Which combination prod
    nsiveness of my list is to send them free gifts. I buy or create short ebooks to
    cts are meaningful and rational?
    Which therapeutic categories to select?
    Which Combinations can address unmet needs of the patients?
    Do combin
    give away as free gifts, and use the ‘free gift’ in my subject on my email campaig
    tions increase the patient compliance?
    What would be the developing cost?
    How to tackle the risks encountered during combination product developmen
    n, and my response rate goes up – and not just for that email, but for following e
    t?

    As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
    ails.

    Another thing that you can do to help improve the responsiveness of your li
    ping new procedures for reviewing their safety, efficacy and quality.

    Professional from academic institutions, pharmaceutical industries, health care indust
    st is to ask questions of your list. Ask them what they want to learn more about.
    y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
    Answer the questions mailbag style – all at once in one big email – you really c
    .

    As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
    eate the illusion of a very responsive list and since people tend to do what other
    elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

    Companies that provide selfless information through particip
    s do – if they see that the rest of the list is responsive, they might do the same


    tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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