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One thing that advertisers love is a responsive E-Zine. Why? Because this gives them an opportunity to get their sales message to marketers wh

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

o are more apt to purchase their products or subscribe to their service. To an E-Zine publisher, this is also gold. Many advertisers means muc

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

revenue. On the surface, this seems like a great thing all the way around. But there is another variable in the equation that cannot be overl

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ooked. That variable is the E-Zine subscriber.

E-Zine subscribers are a touchy lot. They love being given information, especially if it is in

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ormation that is going to solve a problem or earn them money. But the last thing they want is to be sold to. Being made to feel like the only

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

eason for your E-Zine is to get them to buy your, or worse, somebody else's product, is a sure fire way to reduce your E-Zine subscriber base

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

to rubble. You have to be very careful when it comes to placing ads in your E-Zine. How careful?

Again, you need to put yourself in your subs

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ribers shoes. If you're getting an E-Zine a couple of times a week then certainly putting an ad in each issue or one of the two issues is not

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

oing to ruffle many feathers. As long as the ad is more content and very little ad, you should be okay. But what about if you're sending out a

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

daily E-Zine. In the case of an astrological E-Zine, this is very common as there is a different horoscope for every day of the year. If dail

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

subscribers are getting hit with an ad everyday, they are going to start to get a little tired of it.

Then of course there is the issue of j

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

st how many ads to put in your E-Zine. This all depends on how big your E-Zine is. If it's a small E-Zine email of a page or so, you don't wan

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

t to have any more than one ad in it. For one thing, your subscribers are going to feel like they're being hit over the head with a sledge ham

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

er and for another, your advertisers are not going to appreciate being lumped in with a number of other advertisers. The chances of any of the

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ads being read is slim to none. This makes everybody unhappy, the subscribers and the advertisers.

Remember, the primary purpose of your E-Zi

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ne is to provide your subscribers with information. Ultimately, if you provide them with a good E-Zine, with good content and don't inundate t

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

em with tons of advertising, they will appreciate your service and eventually will become customers of you products or services because they t

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ust you. Also, if you treat your advertisers with respect and feature their ad alone in your E-Zine, they will be more likely to make sales an

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

d want to continue to advertise with you. In the long run, by thinking of both sides before thinking of your own pocketbook, you'll be making

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

veryone happy and yourself more profitable as a result.

It's a tough balancing act, but with practice and a little experience, it can be done

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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