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Finally, after all the planning, you have got your content, your advertisers and your subscribers. Your E-Zine is off to the races. Slowly but surely, your s

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

ubscriber list starts to grow. Along the way, you are going to have those who wish to be removed. No problem. You have got such a small list of email address

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

s that doing this manually is a piece of cake. Yeah, it's tedious and boring but it is certainly not hard.

And then the unthinkable happens.

Your E-Zine be

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

gins to take off. Word of it is spreading like wildfire. Your once small email list of subscriber is now into the hundreds or thousands. Suddenly, trying to

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ind somebody in that maze is not easy at all. Handling un-subscribe requests is becoming a nightmare. You're starting to wonder why you ever began to do this

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

in the first place.

Well, before you email everybody on your list and tell them that you're about to shut down because you're having a nervous breakdown, t

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

ere is a solution to your problem, and a very simple solution. Yes, it's going to cost you a few bucks each month, literally, but it will be more than worth

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

it in the long run.

By automating your E-Zine with an auto-responder, you virtually take away all the work of maintaining one, other than just writing the c

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ntent and getting sponsors for your advertising.

So exactly how does this process work?

Well, the first thing you have to do is find a good auto-responder

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

service. There are some very good ones and some not so good ones. Do your research. Usually you get what you pay for. So if you find one for about $5 a month

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

most likely it isn't going to be very good. A decent auto-responder service is probably going to run you about $20 plus a month.

After you find one that yo

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

're happy with the next step is to get your subscribers into it. This means having them re-subscribe. Few auto-responders are going to just let you import na

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

mes. That's fine. You want to make sure that the people on your list still want your service anyway. This will only reaffirm it.

Once the confirmation email

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

go out, the subscriber will have to either have to click on a link or send back an email to be confirmed into the system. After that, handling un-subscribe

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

requests is a piece of cake. Why? Because with each E-Zine that you send out, the auto-responder service will include an un-subscribe link. This way, if the

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

erson no longer wishes to receive your E-Zine, all they have to do is click on the link. Once they do this, they will be brought to a page that tells them th

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

ey have been un-subscribed. At the same time, the auto-responder service itself will remove them from the system. No muss, no fuss.

In the future, to get ne

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

subscriber, all you need to do is include the subscribe email address or link in your E-Zine ad or directory listing. All subscription and opt-outs will be

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

handled automatically at that point. All you need to do is load your E-Zine message into the auto-responder and broadcast it to your subscriber base. Most au

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

o-responders will have this option.

By using auto-responders to automate your E-Zine you will save yourself a lot of headaches and a lot of sleepless nights

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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