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Welcome back. In the last article, I outlined the 3 methods of co registration itself. No matter which one you decide to follow, before you get started, you need to know exactly how to properly and carefully handle co reg leads themselve

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

s. There is a definite reason for this.

In the early days of co registration (think dawn of the internet age and you will understand how wild it was) people were not too concerned about proper handling of co registration leads. They sim

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

ly threw their co reg leads straight into their main email list without a second thought. This led to major headaches which almost caused co registration to totally fall out of favor. The reason is they built big lists, but those lists w

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ere a total mess!

The main reason for this is, believe it or not, is the nature of the internet itself. It allows for a measure of anonymity that no other medium does. People can actually claim they are anyone they care to be and nobody

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

can really check up on it. So people fill out opt in forms with fake data. Some of it led to emails bouncing, some of it went to other people's email in boxes (this is called 'Joe Jobbing'), and some of it went to 'spam box' emails addre

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

ses that never get opened and read.

Today there is a specific vetting process that is done with leads generated via this form of advertising to get around this and other problems. I'll outline the basic process; your lead provider should

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

be giving you specifics on how to do this.

1. Segregate your co registration leads on a separate autoresponder from your main list. Putting them on a separate account on your main autoresponder is simply asking for tro

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ble. It's too easy to make a mistake and mail them something you will regret sending them later, so keep it totally separate to avoid that little problem.

Now some people will tell you to use an in house autoresponder script for your co

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

reg leads. Let me ask you a question: Would you do this with your main email list? If so, then great, spend the money on an autoresponder script for co reg leads, otherwise use a free autoresponder service for this purpose.

2.

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

If your leads are exclusive, and delivered in real time, consider confirmed opt in. Some leads are bogus, some are 'Joe Jobs', and some are going to 'spam email boxes' that won't ever get read anyhow, do you really want these kin

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

of junk leads? A confirmation email will weed these out real quick and painless, so you will only send emails to people who will actually read what you have to say.

3. Warm them up. Let's face it. They do not know y

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ou from Adam. So the first email you actually send them should be nothing more than an introduction. Encourage them to get off this list unless they are serious about reading what you have to say, and do this multiple times. Also reassu

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

e them know you won't share their info, won't send them offers for junk all the time, and outline the info you will be sending them and how long the series will last.

4. Send only content. Do not send them ads in the b

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

eginning, wait at least several emails before pitching anything to them. Of course, if this is to build up a free ezine, you can give them a link to that but it needs to be couched just right.

A good line to send is "If you like this con

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ent, you will find more great info at my ezine at www.yourlinkhere.com". Another one is to say "This trial subscription ends in x emails (note: make sure it does or you will be sorry), if you like this content and want more, go to www.

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ourlinkhere.com and sign up for my free ezine". Use your imagination and come up with a good line that works for you.

5. When done, throw them away. This eliminates the temptation to re mail them, which is a totally fr

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

owned upon practice for obvious reasons. With any autoresponder, it's real easy to sort through them and mass delete any old co reg leads, so there is really no excuse for not doing it.

Following the above practices will ensure your co

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

eg campaigns generate a good responsive list at the end of the campaign, which is what you really want.

The key is to plan this out beforehand so this does not bite you when you least expect it. Write up your warm up email and your conte

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

nt (and your ads, properly put in) first then load this into the autoresponder you choose to use, and then start your co reg campaign. As they say, 'Prior Proper Planning Prevents Poor Performance'.

Now that you got that planned out, wha

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

's next? If you are using personal co registration (the method everyone endorses), you will need joint venture partners. So how do you acquire those? That will be the next subject in this series. Look for it in the next couple of weeks

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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