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The purpose of search engines such as Google and Yahoo is to provide relevant results for their users. Such effective searches require the identification of the most relevant pages and

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

the removal of websites that are using manipulative techniques to try and rank higher. In many cases, techniques are followed which are not only ineffective but can also be considered

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

spam by search engines. We can now look at some of these manipulative techniques that can cause websites to be penalised and even banned by Search Engines.

1. Hidden Text

Hidden tex

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

t is text that users are unable to see when visiting a webpage. For example, this technique is where keywords are placed (usually in a repetitive manner), somewhere on a page and the c

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

olour of the text is the same as the background of the page so that it cannot be seen by visitors to a website. Search engines can detect this and will penalise and even reject such pa

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

ges.

2. Alt Image Tag Spamming

Alt Tag spamming is another way that people try to get keywords into their websites. You can tell when a website is using Alt Tag spamming when you hol

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

d a mouse over an image on a page, a small popup appears and you can see keywords repeated. The Alt Tag is meant to be a textual description of the image it is attached to and it's use

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

can be beneficial to search engine optimisation when used correctly. However, penalisation occurs when an Alt tag has obvious keyword repetition/stuffing that a search engine can reco

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

gnise as spam.

3. Meta Tag Stuffing

Meta Tags are HTML coding which are used to provide information about a web page and are a useful and acceptable way of adding keywords to a page.

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

If a website is trying to rank well for a term such as tents, meta tag stuffing would involve adding the term tents within the meta data repeatedly. Search engines can detect such spa

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ming and will penalise such techniques. Likewise, high traffic keywords are often added into Meta Tags that are completely unrelated to a web page in order to generate more traffic. So

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

me search engines can detect when the keywords in a keyword Meta tag don't match up with the actual content of a site and will penalise such pages.

4. Title Tag Stuffing

The title ta

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

g appears on the top left hand corner of a webpage and is the main information that is displayed in search engine results. Title tags should introduce a website to potential visitors a

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

nd encourage them to click through to a site. Title tag stuffing occurs in a similar fashion to Meta tag stuffing where keywords are entered repeatedly into the title tag. However, sea

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

rch engines place a higher priority on Title Tags than Meta Tags when it comes to ranking websites and the consequences for spamming within the title tag are much more serious.

5. Con

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

tent Duplication

Content duplication is an obvious spamming technique that is becoming more of an issue today. Content duplication issues can occur when content is copied from other w

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

ebsites or when it is copied from other pages within a website. Search engines do not want to be displaying the same pages in their search results and duplication of content may mean t

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

hat search engines don’t index some pages at all. Even worse, a search engine crawling program might stop indexing all of the pages of a site because it finds too many copies of the sa

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

me pages at different websites.

There are many Black Hat techniques that are used to try and influence search engine rankings that can lead to negative effects on search engine visibi

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

lity. Some sites may succeed in getting higher rankings in the short term however these techniques are likely to be spotted quicker as search engines become more and more sophisticated

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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