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Internet search engines are special sites on the Web that are designed to help people find information stored on other sites. There are differences in the ways various search engines work, but they

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

all perform three basic tasks:

- They search the Internet -- or select pieces of the Internet - based on important words.

- They keep an index of the words they find, and where they find them.

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

They allow users to look for words or combinations of words found in that index.

Early search engines held an index of a few hundred thousand pages and documents, and received maybe one or

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

wo thousand inquiries each day. Today, a top search engine will index hundreds of millions of pages, and respond to tens of millions of queries per day.

Spidering

Before a search engine can tell

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ou where a file or document is, it must be found. To find information on the hundreds of millions of Web pages that exist, a search engine employs special software robots, called spiders, to build

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

lists of the words found on Web sites.

When a spider is building its lists, the process is called Web crawling.

In order to build and maintain a useful list of words, a search engine's spiders ha

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

e to look at a lot of pages. How does any spider start its travels over the Web? The usual starting points are lists of heavily used servers and very popular pages. The spider will begin with a pop

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

lar site, indexing the words on its pages and following every link found within the site. In this way, the spidering system quickly begins to travel, spreading out across the most widely used porti

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ns of the Web.

Indexing

Once the spiders have completed the task of finding information on Web pages, the search engine must store the information in a way that makes it useful. There are two key

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

components involved in making the gathered data accessible to users:

-The information stored with the data

-The method by which the information is indexed

In the simplest case, a search engine

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ould just store the word and the URL where it was found. In reality, this would make for an engine of limited use, since there would be no way of telling whether the word was used in an important o

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

a trivial way on the page, whether the word was used once or many times or whether the page contained links to other pages containing the word. In other words, there would be no way of building th

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

ranking list that tries to present the most useful pages at the top of the list of search results.

To make for more useful results, most search engines store more than just the word and URL. An e

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ngine might store the number of times that the word appears on a page. The engine might assign a weight to each entry, with increasing values assigned to words as they appear near the top of the do

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ument, in sub-headings, in links, in the meta tags or in the title of the page. Each commercial search engine has a different formula for assigning weight to the words in its index. This is one of

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

he reasons that a search for the same word on different search engines will produce different lists, with the pages presented in different orders.

An index has a single purpose: It allows informat

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

on to be found as quickly as possible. There are quite a few ways for an index to be built, but one of the most effective ways is to build a hash table. In hashing, a formula is applied to attach a

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

numerical value to each word. The formula is designed to evenly distribute the entries across a predetermined number of divisions. This numerical distribution is different from the distribution of

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

words across the alphabet, and that is the key to a hash table's effectiveness.

The Search Engine Program

The search engine software or program is the final part. When a person requests a search

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

n a keyword or phrase, the search engine software searches the index for relevant information. The software then provides a report back to the searcher with the most relevant web pages listed first

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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