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The first and formal adoption of the world Brahman originated with the inception of the American Brahman Breeders Association (ABBA) in 1924. Cattlemen attending

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

their organizational meeting wrestled with the question of what to name this American Bos Indicus breed that Mr JW Startwelle called “… an entirely new breed of be

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

f cattle”. Mr Startwelle, however the first Secretary of ABBA and early driving force of their association, was indeed historically instrumental, when he suggeste

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

the word Brahman.

The Early History in Southern Africa:

The introduction of the Brahman to the South African beef cattle scene originated back in 1954 when Mr J

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

urgen Crantz, of Windhoek, in South West Africa as they knew it in those days, initially imported eight males and ten females from Texas, USA, to be landed at Cape

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

Town harbour.

Five of these bulls originated from Mr JD Hudgins, Texas, while one came from Mr Albert B Fay, Texas, another one from Mr VW Frost, Texas, as one fr

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

m Laxy 3 Ranch, Texas. All ten females were from the famous JD Hudgins Ranch. We today salute the inspirations and motivations of Mr Jurgen Crantz of Namibi? as

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

the pioneer who unknowingly laid the foundation of what would have become a major breed in the production of red meat in Southern Africa.

Mr W Woker of Windhoek,

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

outh West Africa, Nuanetzi Ranch Ltd., the Normar stud of Mr AI Marais and Mr C Scheepers, all from South Africa made other early imports in 1954. Breeders who we

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

e particularly prominent by importing many animals between 1954 and 1971 were, among others, JFW Herbst and son, JB Orpen of the Bar Circle Stud, Sisal Brahmans of

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

Mr Eric Bilse, Ban Cattle Co. of Mr Louis Bosman, D Terblanche, RELH Hunt, the Code Brahman Stud of Mr AJ Coetzer and Mr BJ Maritz.

The remarkable growth and dema

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

nd for the breed:

The contribution Brahmans have made towards the South African stud and commercial industry can be described as remarkable, especially during the

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

first three decades starting in 1960. The distinctive appearance of the Brahman during the coming decade sets them apart from any other traditional beef breed in

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

outh Africa. The hump on top of its shoulders, large pendulous ears, abundant folds of skin and distinctive colour has contributed towards the phenomenal growth b

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

eing recorded in those days.

The membership of 41 in 1960 increased by 465.85 % within the first ten years, births during the same period by 1 296.64 %, registrat

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ons 581.63 % and transfers by 1 542,64 %. This brought the Brahman into the limelight after only 10 years and remarks by the press such as the “Brahman is like a

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

hameleon because he adapts everywhere” were made in those days. The use of the Brahman as a maternal line has become significant due to the dramatic changes in th

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

e composition of our national beef population in South Africa.

Official figures show that where the Afrikaner represented almost 45 % of the market share in 1965,

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

the situation changed dramatically in 1985 to retain only 7.0 % of the registrations at the SA Stud Book and Livestock Improvement Association. Brahman registrati

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ns on the other hand increased from 4.4 % to almost 57.0 % during the same period. Currently there are 572 members with a total number of +60 000 enrolled animals

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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