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From the minute users log onto their e-mail system, they encounter a deluge of unwanted e-mail that flows into their mailboxes all hours of the day and night. The billions of unwanted email messages circulating across the Internet disrupt email delivery, clog up computer systems, reduce productivity, waste time, raise the cost of Internet access fees, irritate users and erode their confidence in using email. Many s

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

pam messages also contain material that is offensive or fraudulent, and spam is sometimes used to spread computer viruses.

Spam presents three major threats:

Overwhelming message volume. Spam drains employee productivity as workers waste time reading, deleting or even responding to spam e-mails. Additionally, the sexually explicit nature of many spam messages poses potenti

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

l liability for organisations.

Phishing. Phishing is a specific type of spam message that solicits personal information from the recipient, such as social security, credit card and bank account numbers.

Spoofing. Spoofing is a deceptive form of spam that hides the domain of the spammer or the spam's origination point. Spammers often hijack the domains of well-known businesses

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

r government entities to enhance the validity to their commercial message or scam. An example of spoofing is an e-mail that appears to come from a known e-mail address that requests a credit card number to confirm the order of goods.

So what can businesses do to help cut down on spam?

Implementing these basic policies and strategies can help cut down on spam:

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

Get a spam-filter. Your ISP may offer a filter service. If not, you may wish to buy filtering software. There is a wide choice of anti-spam software that offer a free trial period. Remember that one size does not fit all and obviously the best product for a desktop user or small business would not be appropriate or adequate for meeting the needs of a large enterprise.

Establish written gui

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

elines for how corporate e-mail addresses and Web browser are to be used by employees.

Educate users to never respond to an e-mail when the sender is unknown, even to remove themselves from a mailing list.

Be careful about disclosing your e-mail address. Follow these tips whenever you can:

Set up an e-mail address dedicated solely to Web transactions.

Only share your prima

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

y e-mail address with people you know. Avoid listing your e-mail address in large Internet directories.

Don't even post it on your own Web site.

Disguise (or "munge") your e-mail address. Use a munged address whenever you post it to a newsgroup, chat room, or bulletin board. For example, you could give your e-mail address as "s0me0ne@example.c0m" using "0" (zero) instead of "o." A person can interpret your a

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ddress, but the automated programs that spammers use cannot. Another example is me@(nospam)isp.com.au where you advise users that they need to delete the (nospam) element of the address.

Watch out for checked boxes. When you buy things online, companies sometimes add a checkbox (pre-checked!) to indicate that it's fine to sell or give your e-mail address to responsible parties. Click the check box to clear i

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

Encode corporate e-mail addresses posted on company Web sites in Javascript or HTML to hinder a spider’s ability to recognize them. (The e-mail address looks normal and acts normal [to Web site visitors], but from the back end you just see code.)

Even if you’re using anti-spam software, urge users to report spam that sneaks through to a corporate e-mail address for further analysis

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

Decide how much control your company wants over e-mail that’s been deemed spam, and whether end users or the network administrator should manage it.

Educate your end users to identify and report any spam that does get through, and alert them to e-mail fraud. One clue to detect spam is if the sender’s e-mail address differs from the company’s name in the message.

Limit Web surfin

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

on company PCs; an easy way for spammers to find live e-mail addresses is by lifting them from sites where visitors have input their address.

Adjust your Internet Explorer security settings to help prevent unwanted intrusions when you go on the Web. See Working With Internet Explorer 6 Security Settings

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

for detailed directions.

Review the privacy policies of Web sites. When you sign up for Web-based services such as online banking, shopping, or newsletters, review the privacy policy closely before you reveal your e-mail address. If a Web site does not have a privacy statement posted, be cautious and consider contacting the site owners before sharing sensitive information.

Don’t open email

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

that appear to be from a dubious source. It is not wise to open any email message that appears to be from a dubious source. However, if you have already opened the message, don’t click on any links, including the unsubscribe facility – often spammers just include fake unsubscribe facilities in order to confirm that your email address is a real address. If you click ‘unsubscribe’, you may open yourself to a deluge o

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

spam, both from that spammer and from others to whom they sell your email address. Note that for legitimate commercial electronic messages (those that have been sent with your consent), the unsubscribe facility must work, and it should be safe to use the facility.

Don't reply to e-mail asking for personal information. Most legitimate companies will not ask for personal information via e-mail. If a com

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

pany you trust (e.g., your credit card company) writes to ask for personal information, call—do not write—and report it. Be sure to use a number you found yourself, either through the yellow pages, a bank statement, a bill, or other source. (Don't use a phone number provided on the e-mail.) If it's a legitimate request, the phone operator should be able to help you.

Watch out for spoofed mail. "Spoofing"

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

refers to duplicating a legitimate e-mail, such as a company's newsletter. These spoofed mails may be used to trick you into downloading a virus or sending personal information, such as a credit card number. When in doubt, contact the company you think sent the e-mail.

Don't buy anything from a spam mail. Some spammers make their living on people's purchases of their offerings. So resist the temptation t

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

buy their products if you don't want to take the chance of getting on more junk e-mail address lists.

Be careful when downloading Adware, Freeware and Shareware. The process of downloading such software often requires you to provide your email address which may be used to send you advertisements, viruses, more spam or even download secret files into your computer which can compromise your PC's security.

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

Never, ever contribute to a charity from spam mail. Unfortunately, some spammers prey on your good will. If you receive an appeal from a charity, treat it as spam. If it is a charity you would like to support, call them and find out how you can make a contribution. Never send your information via e-mail, however.

Never respond to popups by clicking on links.

Think

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

twice before opening attachments, even if you know the sender. If you cannot confirm with the sender that a message is valid and that an attachment is safe, delete the message immediately, and run up-to-date antivirus software to check your computer for viruses.

Don't forward chain e-mail messages. Chain mails may be hoaxes, or even a virus delivery system. Plus you lose control over who sees your e-mail

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

address. Additionally, there are reports that spammers use chain letters to gather e-mail addresses. To check on the legitimacy of a chain letter or potential hoax, go to Hoaxbusters.

Conclusion

The best defense against Spam is to be pro-active, and ensure that you use common sense when using email and the Internet.

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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All prospects are not created equally. Some are worth the continued investment of your time, resources and energy, while others will only sap your motivation, as well give you ample frustration and send you to an early grave. (Sales grave, that is.) Why do salespeople give these poor prospects more time than they deserve? Here are a few reasons for you to consider

The first day of your new business is here and you have to get out there and secure your first customer. It all looked so easy when you were planning, but now this is real and doesn’t seem as effortless as you thought. What practical steps can you take to ensure your business gets off to a flying start?

In today's swift cyber world, users have become more demanding & unwilling to use the traditional web application that requires time for something to happen after entering the data & clicking the button. Users are no longer interested in slow working or any interruption in their workflow.

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