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I'm sure I'm not the only person on the planet that remembers getting the occasional chain letter in school.. you know, the kind that was actually written with a pen or pencil on paper that told you either something wo

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

nderful would happen or something terrible would happen or both if you did or didn't send out 20 copies within 7 days. Ugh. I still remember my fingers cramping as I tediously re-wrote the letter 20 times and the looks

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

on my friends faces when they realized the note i just passed them was leading them to the same path of wasted paper.

Things have changed a lot since then;

Not just the venue has changed though, now we not only get p

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

oems with promises of good luck or threats of doom for not following instructions, we get petitions, promises of rewards from big companies, plea's to call your local government person because of some pending law that

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ill be devastating to someone or something, and suggestions to boycott popular companies because of some alleged injustice they have performed. (Just imagine the phone calls these companies get!)

I get amusing chain l

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

tters in my email box occasionally mixed in with some urban legends and Christian Internet hoaxes for variety and before I knew better I'd give a little laugh, a roll of the eyes and pass it on to the 10 required frien

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

ds with the promise that something good would happen in 10 days (or that I would escape a horrific tragedy)

Oh but then I learned. I learned about SPAM and about how to finally change my email address when it got over

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

helming!

Perpetuating email chain letters is not a good idea. I read recently that most Internet service providers prohibit it in their terms of service... hmm... I will have to read those terms to see what else I'm n

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ot allowed to do! But it is with good reason that they have these rules.

You know the old 'phrase' I tell 2 friends and they tell 2 friends and they tell 2 friends... yada yada yada... well imagine what happens when y

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

u forward that silly email to your 20 friends and they each send it to their 20 friends... well already you've got 420 copies going out to cyberspace and taking up bandwidth and bogging down servers all over the place

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

especially if your 20 people are co-workers on the same email system!

What else is wrong with it? Well you've just added your name, or at least email address to a long and growing list of which you have no control ov

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

er. This is like sending out an engraved invitation to spammers and scammers all over the world and suddenly the note from Aunt Joan is burried among 50 emails trying to sell you everything from viagra to stocks and bo

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

ds.

So what can you do? Well, the first and most obvious is delete it. But sometimes it's a cute story or a joke or some other reason to smile or chuckle and we all need some of that now and again so you want to forwa

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

rd it? Take these steps to do it safely.

After you've clicked forward go through the email, delete all the email addresses that are hanging on to the mail of all the people that have recieved it with you.

Leave only

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

he portion of the email that you think is funny or cute and take out all the instructions to forward to 10 - 20 - or 50 people and what will happen if you don't

Use the bcc: field for the emails of the people you're g

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ing to send it to to keep their emails from being passed on if one of them chooses to forward it.

Finally, while I definately recommend against it, some people are just too superstisious to let a chain letter break. I

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

f you MUST continue a chain letter, still follow steps 1 and 3 above and get yourself a disposable email address for this purpose. Belive me, if you've never had to change your email address to get rid of the junk, you

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

don't want to find out how fun it is! Remember, it's not just advising your friends and family and co-workers of the new email, but many of your online accounts use your email address if not for signing in, for getting

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

lost passwords etc. How frustrating to go to get the status of some account and when you realize you can't remember the password the only option is to have it emailed to you and you didn't update the account!

So, get

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

a disposable email address and use it for forwarding chain letters (if you have to) but also for signing up for things on the Internet! Then when the spam hits the fan, you can just delete the account and get a new one

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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