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So all of us who have worked on websites before, or even have just browsed the net, have come across something called CSS. If you’re familiar with HTML a

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

t all, you’ve definitely heard the term. With the way that the internet works, there’s always a new update to the way that websites are coded and structu

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

ed. CSS is a fairly new addition to website programmer’s tool box. Today we will be going over the language the history of and the pros of using CSS.

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

>What is CSS?
Cascading Style Sheets, CSS, is a coding language used to describe the presentation of a document written in a markup language suc

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

as HTML. CSS is used by both the authors of web pages to control colors, fonts, layout, and other web page properties. It is used mainly to separate web

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

ite structure from website content. This improves accessibility, flexibility and control of content presentation.

CSS History
Style sheets h

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

ave existed since the beginnings of SGML (Standard Generalized Markup Language) in the 70’s. Cascading Style Sheets were developed for creating a consist

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

nt approach to providing visual presentation information for web documents. As HTML developed over time, it evolved to include a variety of stylistic cap

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

bilities for web developers. This gave designers more control over site appearance but also made HTML more complex to write and maintain.

Web browser va

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

riations made consistency difficult, and web surfers had barely any control over how web pages were displayed. The W3C began working on a new way to cont

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ol visual presentation of web content. Out of 9 different proposed style sheet languages, CSS grew from two of the 9, Cascading HTML Style Sheets (CHSS)

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

nd Stream-based Style Sheet Proposal (SSP). As work was done on the development of these two languages, CHSS took over, and eventually the H was dropped

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

as these style sheets could be used with other markup languages. CSS1 specification was completed in 1996 and Microsoft's Internet Explorer 3 was release

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

with limited support for CSS. In 2000, IE 5 was released, with full CSS support. Right now, most browsers support CSS; Including Mozilla FireFox, Intern

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

t Explorer, and Netscape Navigator. There are a few discrepancies in how each browser interprets certain CSS properties, but these have been solved with

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

CSS hacks, workarounds, and CSS filters in order to obtain consistent results across web browsers.

Pros
Some of the advantages of using CSS

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

re:

• Visual presentation information for an entire website can be held in one CSS file, which allows for changes to be made cross-site quickly.
•

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ifferent users can have different style sheets.
• The document’s code is reduced in size, since it does not need to contain any code pertaining to t

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

he visual presentation of content.
• Pages using CSS are easier to edit in the future.

By no means is this a full explanation of CSS, as that would

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

take many articles to fully explain. But I hope that this article explains a little bit about CSS, how it has developed, and some of the pros of using it

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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Recently a think tank has proposed the franchising of nations. Why you ask? Well because what we are doing with the World Bank, WHO, Catholic Churches, Aid From first worlds, United Nations, Doctors without Borders and Corporate Foundations and Sponsors is mix matched and often leads to chaos

Four percent of the sales people in the U.S. sell 94 percent of the goods and services, according to two meta studies - one by Harvard University and one from the Gallup Organization.

Misunderstandings abound in e-mail. Many times simply due to one side not taking the time to ensure that their message and intent is clear, while the other side reads into the e-mail things that may not be there.

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