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Experience in research and developing the research website has enables Web researchers to model collaboration and connection. The aim of this is to connect all the research that each person has done with research of others. This enables each person to connect with work they would like to have done themselves or can see they should have done, or should get involved

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

in, but haven't had time. This can help business by allowing the business to clarify what it should focus on while knowing who can provide the othre services it needs. The advantages of this understanding of connections are most obvious in software and web development. This idea of connecting research via web links fits in with this quote from Steve Jobs of Apple

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

"Creativity is just connecting things" (Jobs, 1996).

Further research is needed into providing a linking mechanism for 'snippets' of information. People need answers to particular questions they are asking. In order to get the facts they need it is important for the returned information to contain this. Return of the information as factual snippets that can be pi

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ced together into a report with links to the multiple sources would aid this. The work with semantic technologies and languages such as RDF (Resource Description Framework) (World Wide Web Consortium, 2006) and RSS can assist in this. RDF, and Web Ontology Language (OWL) add a layer of standardisation of semantics, above the standardised syntax of XML (extensible

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

arkup Language) (Bechhofer and Carroll, 2004).

RDF

Structuring information makes it easier to export it to different software systems to make his possible. It also makes it possible to provide visual navigation menus with a tree or graph structure. RDF can be searched using SPARQL (SPARQL Protocol And RDF Query Language) (World Wide Web Consortium, 2006).

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

Because a resource can represent anything, knowledge from any domain can theoretically be represented in RDF. This, and its standardised syntax that allows it to be machine understandable, are the reasons why RDF is such a useful and important technology for the Semantic Web. RDF consists of a resource, a property, and a property value. This triple corresponds to

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

subject, predicate, and object in logic. Each RDF triple represents a fact. A Resource is anything that can have a URI (uniform resource identifier). A URI can look like a web address and can actually be a web address, but this is not always the case, it is a way of representing an entity. A URI consists of the name and location of the entity. An RDF Resource is d

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

scribed through a collection of properties and property values called an RDF Description. RDF provides a mechanism for describing collections, which are special kinds of resources, and a sequence is an ordered collection. A collection does not have to possess its own URI but it can. RDF information can link to further RDF information elsewhere, providing connectiv

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ty. This allows resources to be linked to each other indefinitely, which is why it is such an important technology for the Semantic Web. Because it is XML based, an RDF Web page can be linked to an XSL stylesheet to produce a visual representation of the structure This is also explained by (Cayzer, 2004) who uses RDF to provide structure for Semantic blogging. Ore

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

et al (2006) also use this approach of combining RDF and Semantic Seb use with ease of editing in a Semantic Wiki.

RSS

RSS allows web users to more easily find information by subscribing to websites that provide the information they are interested in and update this regularly. RSS is explained in (JISC, 2007) and by Cayzer, (2004) who explains its use in

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

semantic blogging. An RSS feed is a list of articles in the website and a short summary of the article with a link to the full information. Software available on the web or downloadable can track the RSS information for sites the web user subscribes to.

RSS has split into different syntaxes and can stand for RDF Site Summary, Rich Site Summary, Really Simple Synd

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ication, and there is a third alternative called Atom. All of the RSS syntaxes are based on XML and some are also based on RDF. The incompatibilities however do not seem to hinder searches using these formats too much, and use of RSS has become a useful method for making information on the web easier to find.

Tools and browsers are available or becoming availabl

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

for searching RSS feeds. An example of this is the downloadable Flock Browser (2007) that includes an icon by the web address to indicate an RSS feed is available for that page. RSS and Flock projects are also related to the concept of blogging that gives individuals who may not be computer literate the opportunity to put there thoughts onto a web page without ne

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ding to edit HTML. This is a similar concept to that of Wikis such as Wikipedia (2006d). RSS allows for a more structured representation of the contents of a web page or a blog.

Berners-Lee et al (2006) explain "The Web is an engineered space created through formally specified languages and protocols. However, because humans are the creators of Web pages and link

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

between them, their interactions form emergent patterns in the Web at a macroscopic scale." As well as connecting research it is necessary to connect information sources, so this work should be taken further by enabling connectivity between open source ontology, modelling, and visualisation tools, with those tools and applications commonly used in industry and o

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ganisations. These applications already hold large amounts of information, sometimes they are legacy applications that have been filled with information for many years.

References

Bechhofer, S., Carrol, J., 2004. Parsing owl dl: trees or triples?. In: Proceedings of the 13th international conference on World Wide Web, NY, USA, pp 266-275.

Berners-Lee, T.

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

, Hall, W., Hendler, J., Shadbolt, N., Weitzner, D. J., 2006. Creating a Science of the Web. Science 11 August 2006:Vol. 313. no. 5788, pp. 769 - 771. - http://www.webscience.org/publications/.

Cayzer, S., 2004. Semantic Blogging and Decentralized knowledge Management. Communications of the ACM. Vol. 47, No. 12, Dec 2004, pp. 47-52. ACM Press.

Flock Browser, 200

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

. the social web browser http://www.flock.com.

JISC (Joint Information Systems Committee). Technology and Standards Watch. 2007. What is Web 2.0? Ideas, technologies and implications for education http://www.jisc.ac.uk/media/documents/techwatch/tsw0701b.pdf

Oren, E., Breslin, J. G., Decker, S., 2006. How Semantics Make Better Wikis. In: WWW 2006, May 23-26, 2006

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

Edinburgh, Scotland.

What creativity is for Steve jobs? It is all about experience connectivity - http://fgiasson.com/blog/index.php/2005/07/23/what_creativity_is_for_steve_jobs_it_is - Quote from Steve Jobs - "Creativity is just connecting things" - Originally from - From Wired Magazine February 1996 Gary Wolf - Reproduced Here - http://romain-moisescot.com/ste

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

e/more/interviews/PDFs/1996.pdf.

What Is RSS - http://www.xml.com/pub/a/2002/12/18/dive-into-xml.html - O'Reilly XML.com - Mark Pilgrim -December 18, 2002.

World Wide Web Consortium (W3C), 2006. Resource Description Framework (RDF) http://www.w3.org/RDF/.

World Wide Web Consortium (W3C), 2006. SPARQL Query Language for RDF http://www.w3.org/TR/rdf-sparql-query/

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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Signs are very important for a business institution as they form an identity for the organization. Business signboards normally confer details relating to the firm's name, address, and phone number.

The new joy on the internet, the Romanians have discovered flash gaming on their websites.

Remember the day that you got your new computer (or the hand-me down from Uncle Larry) and you pulled that shiny case out of the box? Once you finally had all of the cables properly mangled into an unmanageable ball, you powered on, the screen lit up and off you went. The PC was fast, programs loaded in the blink of an eye, and Internet surfing was a breeze. Those were the days.

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