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CRON is a function in Unix and Linux operating systems which allows you to schedule a job and the job will run at the date and time scheduled until you de

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

lete the CRON statement.

Initially, you may consider this to be too technical for you, but not so if you will carefully read this article. It is a function of which you s

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

ould be aware. Even if you do not need it now, remember about CRON for the day you will need it.

Apache server includes this function and it is easy to use with the graph

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ical interface.

The format for CRON is "CRON * * * * * Command to execute" Each asterisk represents a field in the command and can contain the following

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

alues. If you do not want to specify a value for that particular field, leave the asterisk in that position in the CRON statement line. Each of the five fields is separate

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

d by white space.

Here are the values that each field (left to right) can have other than the asterisk:

Field -------- Value ----- Description

minute ----- 00-59 ------

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

xact minute the cron executes

hour -------- 00-23 ------ hour of the day the cron executes(0 =midnight)

day --------- 01-31 ------ day of the month the cron executes

mo

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

nth ------ 01-12 ------ month of the year the cron executes

weekday --- 00-06 ----- ay of the week the cron executes (Sunday = 0, Monday = 1, Tuesday = 2, etc)

command

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

--varies ------ sequence of commands to execute

What prompted the need for the CRON on our site was our use of the software package that required that we copy the ClickBa

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

nk master file into a file on the Boomer-eZine website periodically so our copy is kept current with the ClickBank master.

Since we get busy and forget to do this weekly,

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

a method to have our web host perform this automatically was the answer.

The CRON function is very flexible and can be set to run on almost any time freq

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ency you can imagine.

If you specify a minute in the first field and an hour (24 hour clock) in the second field and leave all the other fields as asterisks, the specifie

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

d program will run on that hour and minute every day. If you want the program to run twice a day at 10 and 11 AM, you can write the CRON as:

CRON 0 10,11 * * * Co

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

mand to execute With the proper combinations, you can set up a job to run automatically on almost any schedule that you can imagine.

Let's try a few. Write a CRO

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

N to execute on every Sunday at midnight.

If you got "CRON 0 0 * * 0 Command to execute", then you are right. The zero in the first position is on the ho

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

r. The zero in the second position is midnight. The zero in the fifth position (day of the week) is Sunday. This is what we used for our CRON settings for the CD A

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

D Box update.

Set up a CRON to run once per year on the last day of the year at midnight.

CRON 0 0 31 12 * Command to execute If you have a gra

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

hical interface on your web server, it is easy to enter the CRON information

Sometimes the CRON function is difficult to find in your control panel. If you have difficult

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

y finding it, send an email to the support group for your web host and ask if this is available and if so, where is it located.

As I said earlier, you may not need this r

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ght now, but remember it for when it will come in handy for you. It can greatly simplify the work of managing your website.

Copyright 2006 John Howe, Inc.

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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