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Many webmasters wish they got a lot of traffic to their site. A day may come and their website may be very popular in just one day. This could be a reason that unique article is published on their

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

site, or just a simple change in search position results in major search engines. So you get a lot of traffic, but is your server ready for this? Pages may take seconds to load and many visitors

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

may think that the site is not available right now and go somewhere else

Today we will talk about Linux and apache tips and tricks that will help webmaster to tune their dedicated server to handl

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

e high traffic.

How to see that you get a lot of traffic? Check log files, or check traffic rating at alexa

How to see that your server is not capable of handling it? Use uptime command or top c

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ommand. load average: 0.31, 0.46, 0.33 line is to search for. The first number shows current load (1 min average), second and third number show 5 and 15 min load average. If your 5-15 server load

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

average is higher than 10 you have to worry about items discussed below.

Apache configuration

httpd.conf is a file file, usually located at /usr/local/apache/conf/httpd.conf path containing conf

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

iguration settings for apache server. Cannot find the location of the file? Use locate command: >cd / then >locate httpd.conf

Main parameters to tune are.

MaxClients – sets the limit on the num

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ber of simultaneous requests that can be supported. Never set this number to high. Setting MaxClients parameter to a big number will lead to consumption of all available memory on your server and

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

a hard disk swapping may occur. In other words the server will try to use hard disk space as additional memory, which is a very-very slow process. How to detect this? Use top command. Typical outp

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ut of a swap command is shown below. Swap “41852k used” and Mem “624148k used” are two lines to look at. It memory size is approaching to total and swap used is growing then you are in trouble. Ch

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

eck MaxClients parameter. How to find what is the maximum that I can set? Calculate the average of your httpd process, divide total available memory by the average leaving some for the system. E.g

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

. in case of 1 Gig RAM and average httpd process size 7MB on this server it is safe to set it to 100. What to set it to a larger value? Add more physical RAM.

top - 01:04:08 up 4 days, 2:19, 1

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

user, load average: 0.31, 0.46, 0.33
Tasks: 129 total, 1 running, 128 sleeping, 0 stopped, 0 zombie
Cpu(s): 5.0% us, 1.3% sy, 0.3% ni, 87.4% id, 5.6% wa, 0.3% hi, 0.0% si

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

> Mem: 1027668k total, 624148k used, 403520k free, 10300k buffers

Swap: 2048276k total, 41852k used, 2006424k free, 446804k cached

PID USER PR NI VIRT RES SHR S %CPU %M

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

EM TIME+ COMMAND
15856 nobody 15 0 47532 7180 3532 S 3.3 0.7 0:00.17 httpd
16097 nobody 15 0 46736 6036 3212 S 1.3 0.6 0:00.06 httpd

KeepAlive - allows multiple r

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

equests to be sent over the same TCP/IP connection. Turning it on can greatly improve the speed of your server, particularly when you have static pages and are serving quite a bit of images from y

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

our server. An example would be a catalogue site with screenshots. From my experience it is best to keep it On

KeepAliveTimeout – sets the number of seconds that the child httpd process sits and

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

takes memory. From my experience it is best to set it to minimum, 1-3 seconds.

MaxRequestsPerChild – sets how many requests to serve per new httpd child process. You may set it very low, thus con

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

stantly freeing the memory, however on a particular case values like 15 or 20 may work well. As an example our site Filesland.com showing 10 im

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ages per page has this parameter set to 15.

After you change settings in httpd.conf do not forget to restart apache. You may do this from control panel or from command line > service httpd restar

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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