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Keep a note of the following points when designing a web site:

1. Frames: Avoid frames. Though search engines have limited ability to crawl framesets, they have th

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

e following disadvantages:

1.1 Not all search engines have the ability to crawl and index pages using framesets.

1.2 Google discourages using frames, and as per G

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

ogle frames tend to cause problems with search engines. If you use frames, use NOFRAMES tag to include no frames version of the content. Don't just write "This pag

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

requires frames compatible browser, your browser does not support frames".

1.3 Even when search engines crawl and index frames, it may so happen that a page appe

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

aring in search results may just be one frame of a frameset, and the visitor may be taken to a bare page without header and navigation buttons.

1.4 Conceptually, a

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

html page consists of only one frame. When using multiple frames, it essentially mean using multiple html pages within one page. This is against the basic concept

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

f a web page.

2. Graphics:

2.1 Avoid excessive graphics or graphic images that take long time to load.

2.2 Use a feature called anti-aliasing to smoothen the bord

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ers of any text or image that you develop.

2.3 Always use alternate text field when using a graphic. This will allow a description to be displayed on the browser

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

creen even if the graphic display is turned off in the browser. Alternate text is also helpful for search engines in identifying the content.

3. Theme: Use a cons

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

stent theme for your web site. It includes layout, and design. As this is a very subjective matter, it differs from person to person. Try to use colors, fonts, sty

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

es that complement one another. From search engine point of view, avoid excessive formatting. It is not recommended to have HTML tags outweigh your actual content.

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

4. Flash: Please check out Flash advantages and disadvantages (http://website-design.anandsoft.com/flash-web-design.html). The subject has been discussed elaborate

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

y.

5. Meta tags: Always use Title, Description, and Keywords meta tags. Use other meta tags as per the requirement. From Google search engine point of view, Title

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

and Description meta tags are very important.

6. Avoid redirects. Search engines may interpret redirect as spam. The reason being, that a redirected page is seen b

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

y the search engine but not by an individual browsing the site. If at all you need to redirect a page, use permanently 301 redirect. A less preferred option is to

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

se a script with at least 6 seconds of delay in forwarding the visitor to the new destination.

7. Keep the web page within 50-80 KB, so the there won't be noticeab

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

e delay in loading of the web page. If the page has content that takes more time, consider splitting the page into two or more pages. This preferred from search e

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ngines point of view as well. If the content is too long, it is likely that some portion of the page is not indexed by search engines.

8. Use of scripts: Use scrip

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

s only if necessary. It is recommended not to load a web page with too much of script as this is likely to confuse the search engines. Client side scripting reliev

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

s the server from script processing, and loads the page faster.

9. Use H1, H2 tags to identify your content headlines.

10. Validate your web pages after composing

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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