Just Other Articles - Internet and Businesses Online

"Any sufficiently advanced technology is indistinguishable from magic."
-Arthur C. Clarke

Act One: The Pledge
Dear Reader, consider yourself warned! The following

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

paragraphs are not for the faint-hearted. Contained herein lies a feat of daring so bold, so extraordinary, so shocking that it mocks your very understanding of the universe. Best you turn away now, lest the fabric of your reality unravel as

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

so many loose threads; leaving you standing bare and raving mad, forsaken in a wasteland of shattered beliefs.

I'm going to take a run-of-the-mill session-based web application and turn it into a load balanced web farm before you

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

r very eyes - all without making a single coding change to the application. That's right ladies and gentlemen, what you're about to witness is a load balancing technique so ingenious, so perfect that the web server - nay the very web applica

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

tion itself will not even know it is part of a web farm.

Each and every web server in the farm will think it alone is communicating with the client. Each and every web server will record a hit not from the load balancer, but fro

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

the client itself. And finally each and every web server will respond directly back to the client, utterly bypassing the very load balancer that brokered the request to begin with.

No special software will be installed on the w

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

eb servers. No ISAPI filters. No plug-ins or other such nonsense will be required.

Understand! This is hardware load balancing I speak of, pure and simple. Hardware load balancing accomplished without the likes of Zeus, Coyote P

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

oint or even the F5 BigIP. This is organic web farming; hardware load balancing achieved with nothing more than two ordinary servers. And perhaps, a little bit of magic.

Act Two: The Turn
I have before me

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

two Dell PowerEdge 850s, each with but a single Celeron processor and a mere 512 MB of memory. One could use nearly any kind of hardware. We, of course, have our corporate sponsorships to think of.

With a wave of my magic wand,

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

Debian Sarge is installed on both servers. Do not be deceived by its meek and unassuming nature. Renowed for its robustness to hyperbole and found in all 12 world climate zones, Debian Linux stands ably by to perform any task at my bidding.

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

br>
After a sprinkle of additions to the source.list file, I shall now utter the magic words to turn these servers into a high availability pair of load directors: apt-get install ultramonkey. Now with another wave of my wand, I

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

apply the necessary configuration elements to enable the fabled load balancing method known as Direct Routing.

Observe! The default gateway of each web server remains unchanged (and it is not the IP address of the load balancer)

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

. Our web servers do not even know the load balancer exists. Requests are forwarded with their source IP address intact. Each web server replies directly, bypassing the load balancer entirely.

Act Three: The Prestige
cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin
ong>
Still not impressed? Take heed, for I have but two words that will surely sway even the most skeptical of skeptics. Listen carefully, for I shall not repeat myself. The words are View State. That's right, I have accomplishe
tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen
d the implausible, the unthinkable. You'll find no Apaches in this web farm. I present to you Windows Server 2003 and a Microsoft .NET web application.

How many in our audience have tried load balancing a .NET application? If so
t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
then you surely have encountered the dreaded "View State is invalid" error.

If you "fixed" this error by enabling some type of sticky sessions on your load balancer, I applaud you with a tip of my cap and a knowing wink. An hono
ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust
rable mention of your efforts is in order perhaps, but let's be honest. That's not really load balancing is it? In the end each client is bound to a single server. Stickyness is only excusable should your application require SSL.

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
> Behold! I present to you the World's Greatest Unsticky Organic Web Farm. Each incoming request is relayed round-robin style to the next server in the web farm. The View State remains persistent across each different web server, yet no sp
.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
ecial programming or state handling mechanism was employed. In fact, the application developers themselves do not even know the secret. And should one server be unavailable for whatever reason, our load balancers will automatically detect it
elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip
and only send requests to the remaining live servers.

Act Four: The Secret
Everyone knows that a good magician guards the secret to his magic. I have guarded mine on our website (sssh, don't tell anyone)

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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