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The Bank of England have today announced a surprise increase in interest rates, from 5% to 5.25%, in a move seen by many

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

as early action against a rising rate of inflation. While many analysts had been expecting a rise early in 2007, the e

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

act time of the announcement came as a shock to many.

The catalyst for today’s announcement seems to have been the incr

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ease in consumer price inflation, which has risen to 2.7%, the highest rate for more than ten years. Today’s rate rise

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

hould also slow down the over exuberant housing market which was recently beginning to gather more momentum, although th

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

rate rise will be an unwelcome present to many who have recently acquired new homes - some of whom have been stretching

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

their finances to the limit in the pursuit of joining the property ladder.

While today’s interest rate rise is sending

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

a message to UK consumers, it will take some time to filter through into the economy, and market observers are expecting

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

next month’s consumer inflation rate to be even higher, with some forecasting a rate in excess of 3% - well above the go

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

vernments 2% target. We can also expect the usual raft of warnings and comment from the government, as many voters will

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

oon be feeling the pinch in the run up to the next general election.

The interest rate announcement caused a fall on th

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

stockmarket, where analysts are now trimming their economic and business growth forecasts for the immediate future. As

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

we have experienced in recent times, we have something of a two tier economic cycle with many companies still strugglin

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

to survive, while the consumer continues to rack up vast amounts of debt in a spend spend frenzy.

In the small print o

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

another announcement today, we also learned that housing repossessions are on the rise with many homeowners hit by inte

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

rest rate increases towards the end of last year. After financing their house price purchases on tight budgets, today’s

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

ncrease will also cause heartache for many more on the property ladder.

While the Bank of England have been warning abo

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

t a situation of “over exuberance” for some time, this rate rise will likely be followed by another in the short term as

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

they attempt to nip in the bud, what could become a very uncomfortable situation. Financial markets are braced for fur

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

her bad news on the economic front in the short term, although how far interest rates will need to rise is not yet clear

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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